Cohort #2: “low dose” hGRP transplantation with FK-506/Rapamycin did not protect respiratory function or cervical motor neurons.

<p>All SOD1^G93A animals had significantly reduced phrenic CMAP amplitudes at 120 days of age (<b>A</b>), demonstrating that SOD1^G93A-mediated disease results in compromised respiratory function; however, there was no significant difference between hGRP and hF groups (<b>B</b>). Cervical motor neurons (denoted by arrowheads) were counted throughout the cervical enlargement in cresyl violet stained sections (<b>C</b>). There was no difference in cervical motor neuron survival between mice receiving hGRP and hF transplants at disease endstage (<b>D</b>). Scale bars: 50 µm.